Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections.

ABSTRACT:

Introduction

COVID-19 has a wide disease spectrum ranging from asymptomatic to severe. While humoral immune responses are critical in preventing infection, the immune mechanisms leading to severe disease, and the identification of biomarkers of disease progression and/or resolution of the infection remains to be determined.

Methods

Plasma samples were obtained from infections during the initial wave of ancestral wildtype SARS-CoV-2 and from vaccine breakthrough infections during the wave of Delta variant, up to six months post infection. The spike-specific antibody profiles were compared across different severity groups and timepoints.

Results

We found an association between spike-specific IgM, IgA and IgG and disease severity in unvaccinated infected individuals. In

SUBMITTER: Goh YS 

PROVIDER: S-EPMC9723332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature