Extracorporeal carbon dioxide removal in acute hypoxaemic respiratory failure: a systematic review, Bayesian meta-analysis and trial sequential analysis.

ABSTRACT:

Purpose

To assess the safety and efficacy of extracorporeal carbon dioxide removal (ECCO₂R) versus standard care in patients with acute hypoxaemic respiratory failure (AHRF).

Methods

MEDLINE, Embase and clinical trial registries were searched from 1994 to 31 December 2021. We included randomised controlled trials (RCTs) and observational studies. Pairs of reviewers independently extracted data and assessed the risk of bias. The primary outcome was mortality. Secondary outcomes included ventilator-free days, length of stay, safety and adverse events and physiological changes. As a primary analysis, we performed a meta-analysis of mortality until day 30 using a Bayesian random effects model. We then performed a trial sequential analysis of RCTs.

Results

SUBMITTER: Millar JE 

PROVIDER: S-EPMC9724795 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature