Rapid Quantification of Pharmaceuticals via ¹H Solid-State NMR Spectroscopy.

ABSTRACT: The physicochemical properties of active pharmaceutical ingredients (APIs) can depend on their solid-state forms. Therefore, characterization of API forms is crucial for upholding the performance of pharmaceutical products. Solid-state nuclear magnetic resonance (SSNMR) spectroscopy is a powerful technique for API quantification due to its selectivity. However, quantitative SSNMR experiments can be time consuming, sometimes requiring days to perform. Sensitivity can be considerably improved using ¹H SSNMR spectroscopy. Nonetheless, quantification via ¹H can be a challenging task due to low spectral resolution. Here, we offer a novel ¹H SSNMR method for rapid API quantification, termed CRAMPS-MAR. The technique is based on combined rotation and multiple-puls

SUBMITTER: Wong YTA 

PROVIDER: S-EPMC9730298 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature