Effector Memory-Expressing CD45RA (TEMRA) CD8⁺ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses.

ABSTRACT:

Background

The mechanisms regulating CD8⁺ T cell migration to nonlymphoid tissue during inflammation have not been fully elucidated, and the migratory properties of effector memory CD8⁺ T cells that re-express CD45RA (TEMRA CD8⁺ T cells) remain unclear, despite their roles in autoimmune diseases and allotransplant rejection.

Methods

We used single-cell proteomic profiling and functional testing of CD8⁺ T cell subsets to characterize their effector functions and migratory properties in healthy volunteers and kidney transplant recipients with stable or humoral rejection.

Results

We showed that humoral rejection of a kidney allograft is associated with an accumulation of cytolytic TEMRA CD8⁺ T cells in blood and kidn

SUBMITTER: Doan Ngoc TM 

PROVIDER: S-EPMC9731633 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature