Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes.

ABSTRACT:

Aims

Cardiac electrophysiological heterogeneity includes: (i) regional differences in action potential (AP) waveform, (ii) AP waveform differences in cells isolated from a single region, (iii) variability of the contribution of individual ion currents in cells with similar AP durations (APDs). The aim of this study is to assess intra-regional AP waveform differences, to quantify the contribution of specific ion channels to the APD via drug responses and to generate a population of mathematical models to investigate the mechanisms underlying heterogeneity in rabbit ventricular cells.

Methods and results

APD in ∼50 isolated cells from subregions of the LV free wall of rabbit hearts were measured using a voltage-sensitive dye. When stimulated at 2 Hz, average APD90 value in cel

SUBMITTER: Lachaud Q 

PROVIDER: S-EPMC9732512 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature