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Mission-critical tasks for assessing risks from vestibular and sensorimotor adaptation during space exploration.

ABSTRACT: To properly assess the risk induced by vestibular and sensorimotor adaptation during exploration missions, we examined how long-duration stays on the International Space Station affect functional performance after gravity transitions. Mission-critical tasks that challenge the balance and the locomotion control systems were assessed: i.e., sit-to-stand, recovery-from-fall, tandem-walk, and walk-and-turn. We assessed 19 astronauts, including 7 first-time flyers and 12 experienced flyers, before their flight, a few hours after landing, and then 1 day and 6-11 days later. Results show that adaptation to long-term weightlessness causes deficits in functional performance immediately after landing that can last for up to 1 week. No differences were observed between first-time and experienced astronaut groups. These data suggest that additional sensorimotor-based countermeasures may be necessary to maintain functional performance at preflight levels when landing on planetary surfaces after a long period in weightlessness.

SUBMITTER: Clement G

PROVIDER: S-EPMC9733831 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Mission-critical tasks for assessing risks from vestibular and sensorimotor adaptation during space exploration.

Clément Gilles G Moudy Sarah C SC Macaulay Timothy R TR Bishop Michael O MO Wood Scott J SJ

Frontiers in physiology 20221125

To properly assess the risk induced by vestibular and sensorimotor adaptation during exploration missions, we examined how long-duration stays on the International Space Station affect functional performance after gravity transitions. Mission-critical tasks that challenge the balance and the locomotion control systems were assessed: i.e., sit-to-stand, recovery-from-fall, tandem-walk, and walk-and-turn. We assessed 19 astronauts, including 7 first-time flyers and 12 experienced flyers, before th ...[more]

PMID: 36505047

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Project description:Background: Anatomical differences between sexes in the vestibular system have been reported. It has also been demonstrated that there is a sex difference in balance control while standing on vestibular-demanding tasks. In 2024, NASA expects to send the first female to the Moon. Therefore, to extend the current knowledge, this study attempted to examine whether different sexes respond differently to vestibular-disrupted and vestibular-demanding environments. Method: A total of fifteen males and fifteen females participated in this study. The vestibular function was quantified through different SOT conditions (SOT1: baseline; SOT5: vestibular demanding by standing with blindfolded and sway reference surface). The vestibular stimulation (VS) was applied either unilaterally or bilaterally to vestibular system to induce the sensory-conflicted and challenging tasks. Thus, a total of 6 conditions (2 SOT conditions X 3 VSs: no-VS, unilateral VS, and bilateral VS) were randomly given to these participants. Three approaches can be quantified the balance control: 1) the performance ratio (PR) of center of gravity trajectories (CoG), 2) the sample entropy measure (SampEn) of CoG, and 3) the total traveling distance of CoG. A mixed three-way repeated ANOVA measure was used to determine the interaction among the sex effect, the effect of SOT, and the effect of VS on balance control. Results: A significant sex effect on balance control was found in the PR of CoG in the anterior-posterior (AP) direction (p = 0.026) and in the SampEn of CoG in both AP and medial-lateral (ML) directions (p = 0.025, p < 0.001, respectively). Also, a significant interaction among the sex effect, the effect of SOT, and the effect of VS on balance control was observed in PR of CoG in the ML direction (p < 0.001), SampEn of CoG in the AP and ML directions (p = 0.002, p < 0.001, respectively), and a traveling distance in AP direction (p = 0.041). Conclusion: The findings in the present study clearly revealed the necessity to take sex effect into consideration while standing in vestibular-perturbed or/and vestibular demanding tasks. Also, the results in the present study could be a fundamental reference for future sensorimotor training.

Project description:Galvanic vestibular stimulation (GVS) is a non-invasive method of electrically stimulating the vestibular system. We investigated whether the application of GVS can alter the learning of new functional mobility and manual control tasks and whether learning can be retained following GVS application. In a between-subjects experiment design, 36 healthy subjects performed repeated trials, capturing the learning of either (a) a functional mobility task, navigating an obstacle course on a compliant surface with degraded visual cues or (b) a manual control task, using a joystick to null self-roll tilt against a pseudo-random disturbance while seated in the dark. In the "learning" phase of trials, bilateral, bipolar GVS was applied continuously. The GVS waveform also differed between subjects in each task group: (1) white noisy galvanic vestibular stimulation (nGVS) at 0.3 mA (2) high-level random GVS at 0.7 mA (selected from pilot testing as destabilizing, but not painful), or (3) with the absence of stimulation (i.e., sham). Following the "learning" trials, all subjects were blindly transitioned to sham GVS, upon which they immediately completed another series of trials to assess any aftereffects. In the functional mobility task, we found nGVS significantly improved task learning (p = 0.03, mean learning metric 171% more than the sham group). Further, improvements in learning the functional mobility task with nGVS were retained, even once the GVS application was stopped. The benefits in learning with nGVS were not observed in the manual control task. High level GVS tended to inhibit learning in both tasks, but not significantly so. Even once the high-level stimulation was stopped, the impaired performance remained. Improvements in learning with nGVS may be due to increased information throughput resulting from stochastic resonance. The benefit of nGVS for functional mobility, but not manual control nulling, may be due to the multisensory (e.g., visual and proprioceptive), strategic, motor coordination, or spatial awareness aspects of the former task. Learning improvements with nGVS have the potential to benefit individuals who perform functional mobility tasks, such as astronauts, firefighters, high performance athletes, and soldiers.

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Mission-critical tasks for assessing risks from vestibular and sensorimotor adaptation during space exploration.

Publications

Mission-critical tasks for assessing risks from vestibular and sensorimotor adaptation during space exploration.

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