Ontology highlight
ABSTRACT:
SUBMITTER: Kaiser M
PROVIDER: S-EPMC9734556 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Kaiser Marina M Lüdtke Timo H TH Deuper Lena L Rudat Carsten C Christoffels Vincent M VM Kispert Andreas A Trowe Mark-Oliver MO
Nature communications 20221209 1
The auditory function of the mammalian cochlea relies on two types of mechanosensory hair cells and various non-sensory supporting cells. Recent studies identified the transcription factors INSM1 and IKZF2 as regulators of outer hair cell (OHC) fate. However, the transcriptional regulation of the differentiation of inner hair cells (IHCs) and their associated inner supporting cells (ISCs) has remained enigmatic. Here, we show that the expression of the transcription factor TBX2 is restricted to ...[more]