When the Gates Swing Open Only: Arrhythmia Mutations That Target the Fast Inactivation Gate of Nav1.5.
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ABSTRACT:
SUBMITTER: Gamal El-Din TM
PROVIDER: S-EPMC9735811 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
When the Gates Swing Open Only: Arrhythmia Mutations That Target the Fast Inactivation Gate of Na<sub>v</sub>1.5.
Cells 20221122 23
Na<sub>v</sub>1.5 is the main voltage-gated sodium channel found in cardiac muscle, where it facilitates the fast influx of Na<sup>+</sup> ions across the cell membrane, resulting in the fast depolarization phase-phase 0 of the cardiac action potential. As a result, it plays a major role in determining the amplitude and the upstroke velocity of the cardiac impulse. Quantitively, cardiac sodium channel activates in less than a millisecond to trigger the cardiac action potential and inactivates wi ...[more]
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