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Lead/Drug Discovery from Natural Resources.

ABSTRACT: Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.

SUBMITTER: Xu Z

PROVIDER: S-EPMC9736696 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Lead/Drug Discovery from Natural Resources.

Xu Zhihong Z Eichler Barrett B Klausner Eytan A EA Duffy-Matzner Jetty J Zheng Weifan W

Molecules (Basel, Switzerland) 20221128 23

Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or ...[more]

PMID: 36500375

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