Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy.
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ABSTRACT:
SUBMITTER: Alam R
PROVIDER: S-EPMC9738281 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
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Canonical and Noncanonical ER Stress-Mediated Autophagy Is a Bite the Bullet in View of Cancer Therapy.
Alam Rashedul R Kabir Mohammad Fazlul MF Kim Hyung-Ryong HR Chae Han-Jung HJ
Cells 20221125 23
Cancer cells adapt multiple mechanisms to counter intense stress on their way to growth. Tumor microenvironment stress leads to canonical and noncanonical endoplasmic stress (ER) responses, which mediate autophagy and are engaged during proteotoxic challenges to clear unfolded or misfolded proteins and damaged organelles to mitigate stress. In these conditions, autophagy functions as a cytoprotective mechanism in which malignant tumor cells reuse degraded materials to generate energy under adver ...[more]
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