Association between Depression, Anxiety Symptoms and Gut Microbiota in Chinese Elderly with Functional Constipation.

ABSTRACT: This study aimed to investigate the relationship between anxiety, depression, and gut microbiota in elderly patients with FC.

Methods

in this cross-sectional study, a total of 198 elderly participants (85 male and 113 female) aged over 60 years were recruited. The study was conducted in Changsha city, China. The participants completed an online questionnaire, including The Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), The Patient Assessment of Symptoms (PAC-SYM), and The Patient Assessment of Quality of Life (PAC-QoL). We selected the 16S rDNA V3 + V4 region as the amplification region and sequenced the gut microbiota using the Illumina Novaseq PE250 high-throughput sequencing platform.

Results

in total, 30.3% of patients with constipation ha

SUBMITTER: Liang J 

PROVIDER: S-EPMC9740187 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature