Dataset Information

Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.

ABSTRACT:

Introduction

Since the beginning of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic an important tool for patients with Coronavirus Disease 2019 (COVID-19) has been the computed tomography (CT) scan, but not always available in some settings The aim was to find a cut-off that can predict worsening in patients with COVID-19 assessed with a computed tomography (CT) scan and to find laboratory, clinical or demographic parameters that may correlate with a higher CT score.

Methods

We performed a multi-center, observational, retrospective study involving seventeen COVID-19 Units in southern Italy, including all 321 adult patients hospitalized with a diagnosis of COVID-19 who underwent at admission a CT evaluated using Pan score.

Results

Considering the clinical outcome and Pan score, the best cut-off point to discriminate a severe outcome was 12.5. High lactate dehydrogenase (LDH) serum value and low PaO2/FiO2 ratio (P/F) resulted independently associated with a high CT score. The Area Under Curve (AUC) analysis showed that the best cut-off point for LDH was 367.5 U/L and for P/F 164.5. Moreover, the patients with LDH> 367.5 U/L and P/F < 164.5 showed more frequently a severe CT score than those with LDH< 367.5 U/L and P/F> 164.5, 83.4%, vs 20%, respectively.

Conclusions

A direct correlation was observed between CT score value and outcome of COVID-19, such as CT score and high LDH levels and low P/F ratio at admission. Clinical or laboratory tools that predict the outcome at admission to hospital are useful to avoiding the overload of hospital facilities.

SUBMITTER: Russo A

PROVIDER: S-EPMC9743688 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.

Russo Antonio A Pisaturo Mariantonietta M De Luca Ilaria I Schettino Ferdinando F Maggi Paolo P Numis Fabio Giuliano FG Gentile Ivan I Sangiovanni Vincenzo V Rossomando Anna Maria AM Gentile Valeria V Calabria Giosuele G Rescigno Caroliona C Megna Angelo Salomone AS Masullo Alfonso A Manzillo Elio E Russo Grazia G Parrella Roberto R Dell'Aquila Giuseppina G Gambardella Michele M Ponticiello Antonio A Reginelli Alfonso A Coppola Nicola N

Journal of infection and public health 20221212 1

<h4>Introduction</h4>Since the beginning of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) pandemic an important tool for patients with Coronavirus Disease 2019 (COVID-19) has been the computed tomography (CT) scan, but not always available in some settings The aim was to find a cut-off that can predict worsening in patients with COVID-19 assessed with a computed tomography (CT) scan and to find laboratory, clinical or demographic parameters that may correlate with a higher CT ...[more]

PMID: 36521329

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Dataset Information

Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.

Introduction

Methods

Results

Conclusions

Publications

Lactate dehydrogenase and PaO2/FiO2 ratio at admission helps to predict CT score in patients with COVID-19: An observational study.

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