Comparison of Bayesian-derived and first-order analytic equations for calculation of vancomycin area under the curve.

ABSTRACT:

Introduction

Consensus guidelines recommend targeting a vancomycin area under the curve to minimum inhibitory concentration (AUC₂₄ :MIC) ratio of 400-600 to improve therapeutic success and reduce nephrotoxicity. Although guidelines specify either Bayesian software or first-order equations may be used to estimate AUC₂₄ , there are currently no large studies directly comparing these methods.

Objective

To compare calculated vancomycin AUC₂₄ using first-order equations with two-drug concentrations at steady state to Bayesian two- and one-concentration estimations.

Methods

This was a single-center, retrospective cohort study of 978 adult hospitalized patients receiving intravenous vancomycin between 2017 and 2019. Patients were included if

SUBMITTER: Olney KB 

PROVIDER: S-EPMC9750735 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature