A novel approach for quantitative electrogram analysis for driver identification: Implications for ablation in persistent atrial fibrillation.

ABSTRACT:

Objective

This study sought to study the feasibility, efficacy, and safety of using multiscale entropy (MSE) analysis to guide catheter ablation for persistent atrial fibrillation (PsAF) and predict ablation outcomes.

Methods

We prospectively enrolled 108 patients undergoing initial ablation for PsAF. MSE was calculated based on bipolar intracardiac electrograms (iEGMs) to measure the dynamical complexity of biological signals. The iEGMs data were exported after pulmonary vein isolation (PVI), then calculated in a customed platform, and finally re-annotated into the CARTO system. After PVI, regions of the highest mean MSE (mMSE) values were ablated in descending order until AF termination, or three areas had been ablated.

Results

Baseline characteristics were evenly d

SUBMITTER: Shi WR 

PROVIDER: S-EPMC9751199 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature