Understanding International Variations in Kidney Failure Incidence and Initiation of Replacement Therapy.

ABSTRACT:

Introduction

Incidence of kidney replacement therapy (KRT) varies widely across countries. Its relations to individual characteristics, nephrology practices for slowing chronic kidney disease (CKD) progression, and KRT access remain unclear.

Methods

We investigated intercountry differences in kidney failure (KF) rate, defined by a sustained estimated glomerular filtration rate (eGFR) <15 ml/min per 1.73 m², and separately in KRT incidence, before and after adjusting for risk factors and blood pressure (BP) control or renin-angiotensin-aldosterone system inhibitor (RAASi) prescription practices in the CKD Outcomes and Practice Patterns Study (CKDopps) cohort study.

Results

Among 7381 patients with CKD stage 3 to 4 at enrollment, 1297 progressed to KF and 947

SUBMITTER: Alencar de Pinho N 

PROVIDER: S-EPMC9751841 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature