Sirtuin 1 aggravates hypertrophic heart failure caused by pressure overload via shifting energy metabolism.

ABSTRACT: Sirtuin1 (SIRT1) is involved in regulating substrate metabolism in the cardiovascular system. Metabolic homeostasis plays a critical role in hypertrophic heart failure. We hypothesize that cardiac SIRT1 can modulate substrate metabolism during pressure overload-induced heart failure. The inducible cardiomyocyte Sirt1 knockout (icSirt1^-/-) and its wild type littermates (Sirt1^f/f) C57BL/6J mice were subjected to transverse aortic constriction (TAC) surgery to induce pressure overload. The pressure overload induces upregulation of cardiac SIRT1 in Sirt1^f/f but not icSirt1^-/- mice. The cardiac contractile dysfunctions caused by TAC-induced pressure overload occurred in Sirt1^f/f but not in icSirt1^-/- mice. Intriguingly, Sirt1

SUBMITTER: Van Le TN 

PROVIDER: S-EPMC9752708 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature