The oral microbiome in young women at different stages of periodontitis: Prevotella dominant in stage III periodontitis.

ABSTRACT:

Objective

Periodontitis progression is related to the dynamic dysbiosis of oral microbiome. We identified the dominant bacteria and the potential pathway in young women with stage-III periodontitis.

Materials and methods

Samples of subgingival plaque were collected from 26 young women with periodontitis (20 with stage-I and 6 with stage-III). Using 16S rRNA-sequencing, we determined the variation in oral bacterial communities of the two groups, and identified the dominant bacteria of each group. We used the Kyoto Encyclopedia of Genes and Genomes (KEGG) database to evaluate the signaling pathways related to the difference in oral bacterial composition. The role of the dominant bacteria of stage-III periodontitis was investigated in vivo and in vitro using an en

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9753221 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature