Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages.

ABSTRACT:

Background

There is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation and activation. However, there has been limited coordinated investigation of common epigenetic pathways among cell lineages. Further, it remains unclear if long-lived memory cell subtypes differentiate distinctly by cell lineages.

Results

We used the Illumina EPIC array to investigate the consistency of DNA methylation in B cell, CD4 T, and CD8 T naïve and memory cells states. In the process of naïve to memory activation across the three lineages, we identify considerable shared epigenetic regulation at the DNA level for immune memory generation. Further, in central to effector memory differentiation, our analyses revealed speci

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9753273 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature