Exercise capacity and physical activity in COPD patients treated with a LAMA/LABA combination: a systematic review and meta-analysis.

ABSTRACT:

Background

Persistent airflow limitation and dyspnoea may reduce chronic obstructive pulmonary disease (COPD) patients exercise capacity and physical activity, undermining their physical status and quality of life. Long-acting muscarinic antagonists and long-acting beta-2 agonists (LAMA/LABA) combinations are amongst moderate-to-severe COPD recommended treatments. This article analyses LAMA/LABA combinations effect on COPD patients exercise capacity and physical activity outcomes.

Methods

A systematic review and meta-analysis of double-blind randomized controlled trials comparing LAMA/LABA combinations against monotherapy or placebo was conducted.

Results

Seventeen articles were identified (N = 4041 patients). In endurance shuttle walk test and constant work rate cycl

SUBMITTER: Miravitlles M 

PROVIDER: S-EPMC9753337 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature