A broad assessment of covid-19 vaccine safety using tree-based data-mining in the vaccine safety datalink.

ABSTRACT:

Background

Except for spontaneous reporting systems, vaccine safety monitoring generally involves pre-specifying health outcomes and post-vaccination risk windows of concern. Instead, we used tree-based data-mining to look more broadly for possible adverse events after Pfizer-BioNTech, Moderna, and Janssen COVID-19 vaccination.

Methods

Vaccine Safety Datalink enrollees receiving ≥1 dose of COVID-19 vaccine in 2020-2021 were followed for 70 days after Pfizer-BioNTech or Moderna and 56 days after Janssen vaccination. Incident diagnoses in inpatient or emergency department settings were analyzed for clustering within both the hierarchical ICD-10-CM code structure and the post-vaccination follow-up period. We used the self-controlled tree-temporal scan statistic and TreeScan sof

SUBMITTER: Yih WK 

PROVIDER: S-EPMC9755007 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature