Ontology highlight
ABSTRACT:
SUBMITTER: Yao J
PROVIDER: S-EPMC9756136 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Yao Jinjing J Chen S R Wayne SRW
Frontiers in pharmacology 20221124
For decades, the amyloid cascade hypothesis has been the leading hypothesis in studying Alzheimer's disease (AD) pathology and drug development. However, a growing body of evidence indicates that simply removing amyloid plaques may not significantly affect AD progression. Alternatively, it has been proposed that AD progression is driven by increased neuronal excitability. Consistent with this alternative hypothesis, recent studies showed that pharmacologically limiting ryanodine receptor 2 (RyR2 ...[more]