Generalisability of randomised trials evaluating perioperative β-blocker therapy in noncardiac surgery.

ABSTRACT:

Background

The limited applicability of evidence from RCTs in real-word practice is considered a potential bottleneck for evidence-based practice but rarely systematically assessed. Using our failure to recruit patients into a perioperative beta-blocker trial, we set out to analyse the restrictiveness and generalisability of trial eligibility criteria in a real-world cohort.

Methods

We prospectively included adult patients (≥18 yr) scheduled for elective noncardiac surgery at an academic tertiary care facility who were screened for inclusion in a planned perioperative beta-blocker RCT, which was terminated owing to recruitment failure. The primary outcome was the proportion of screened patients who matched the eligibility criteria of 36 published RCTs included in a large Coc

SUBMITTER: Titz M 

PROVIDER: S-EPMC9756304 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature