Induction of protective interferon-β responses in murine osteoblasts following Staphylococcus aureus infection.

ABSTRACT:

Introduction

The refractory and recurrent nature of chronic staphylococcal osteomyelitis may be due, at least in part, to the ability of Staphylococcus aureus to invade and persist within bone-forming osteoblasts. However, osteoblasts are now recognized to respond to S. aureus infection and produce numerous immune mediators and bone regulatory factors that can shape the host response. Type I interferons (IFNs) are best known for their antiviral effects, but it is becoming apparent that they impact host susceptibility to a wide range of pathogens including S. aureus.

Methods

Here, we have assessed the local expression of IFN-β by specific capture ELISA in an established in vivo mouse model of staphylococcal osteomyelitis. RNA Tag-Seq analysi

SUBMITTER: Johnson MB 

PROVIDER: S-EPMC9757064 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature