β-Endorphin mediates radiation therapy fatigue.
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ABSTRACT:
SUBMITTER: Hermann AL
PROVIDER: S-EPMC9757747 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
β-Endorphin mediates radiation therapy fatigue.
Hermann Andrea L AL Fell Gillian L GL Kemény Lajos V LV Fung Claire Y CY Held Kathryn D KD Biggs Peter J PJ Rivera Phillip D PD Bilbo Staci D SD Igras Vivien V Willers Henning H Kung Jong J Gheorghiu Liliana L Hideghéty Katalin K Mao Jianren J Woolf Clifford J CJ Fisher David E DE
Science advances 20221216 50
Fatigue is a common adverse effect of external beam radiation therapy in cancer patients. Mechanisms causing radiation fatigue remain unclear, although linkage to skin irradiation has been suggested. β-Endorphin, an endogenous opioid, is synthesized in skin following genotoxic ultraviolet irradiation and acts systemically, producing addiction. Exogenous opiates with the same receptor activity as β-endorphin can cause fatigue. Using rodent models of radiation therapy, exposing tails and sparing v ...[more]
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