Surgical resection versus biopsy in the treatment of primary central nervous system lymphoma: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Despite the improvement in treatment and prognosis of primary central nervous system lymphoma (PCNSL) over the last decades, the 5-year survival rate is approximately 30%; thus, new therapeutic approaches are needed to improve patient survival. The study's aim was to evaluate the role of surgical resection of PCNSL.

Methods

Primary outcomes were the overall survival (OS) and progression-free survival (PFS) of patients with PCNSL who underwent surgical resection versus biopsy alone. The meta-analysis was conducted to calculate pooled hazard ratios (HRs) under a random-effects model for the time-to-event variables. The odds ratios (ORs) were calculated for binary, secondary outcome parameters.

Results

Seven studies (n = 1046) were included. We found that surgica

SUBMITTER: Chojak R 

PROVIDER: S-EPMC9758097 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature