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A novel ReS2–Nb2CTx composite as a sensing platform for ultrasensitive and selective electrochemical detection of dipyramidole from human serum

ABSTRACT: The electrochemical detection of dipyridamole (DIPY) is highly essential since it is extensively used for the treatment of cardiovascular diseases and to impart inhibitory effects for cancer patients. In this work, we report the development of a novel composite of MXene and ReS2 (ReS2–Nb2CTx) by hydrothermal method. It was found that Nb2CTx was partially oxidized and ReS2 nanoparticles were distributed on the surface of Nb2CTx during the hydrothermal synthesis. The ReS2–Nb2CTx was used to modify carbon cloth electrodes and used for the electrochemical detection of DIPY. The ratio of ReS2 was optimized in the composite by varying the atomic ratio from 4 to 9 and it was found that 6ReS2–Nb2CTx showed the best sensing characteristics owing to the optimum interaction between ReS2 and Nb2CTx. The developed sensor was able to detect DIPY linearly in the range 100 pM–1 μM and achieved a limit of detection of (LOD) of 28 pM. The modified electrode exhibited excellent selectivity towards DIPY in the presence of other interferents in addition to its good storage stability and repeatability. Furthermore, the developed sensor was also used for the detection of DIPY in human serum samples. Thus, this work paves the way to develop MXene-based platform for fabrication of flexible device capable of monitoring the acute levels of DIPY.

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Supplementary Information

The online version contains supplementary material available at 10.1007/s41127-022-00055-x.

SUBMITTER: Ankitha M

PROVIDER: S-EPMC9758462 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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