Dataset Information

Tissue factor as a new target for tumor therapy-killing two birds with one stone: a narrative review.

ABSTRACT:

Background and objective

Cancer is an important disease and can occur anywhere in the body. It is caused by uncontrolled cell growth that spreads to other body parts. This study extensively investigated the transmembrane receptor tissue factor (TF), which is the key motivator of the clotting cascade and plays an essential role in cancer-associated coagulation. TF is considered to be aberrantly expressed in various tumors and appears to promote tumor angiogenesis and metastasis. Therefore, this study was performed to explain the pathological characteristics of TF expression and to discuss future cancer therapies that target TF.

Methods

We extensively reviewed the literature on TF published in PubMed, and discussed the effect of TF on tumor progression and TF-targeted therapeutics.

Key content and findings

This review aimed to uncover how TFs contribute to tumor progression and cancer-associated thrombosis and summarize TF-based targeted therapy. Multiple functions and mechanisms of the TF in cancer-associated thrombosis and tumor progression were discussed.

Conclusions

The current literature has confirmed that the TF is involved in the hypercoagulable state of tumors and promotes malignant tumors through coagulation-dependent or non-coagulation-dependent pathways. TF-dependent signaling is also involved in divergent cancer progression. Thus, TF-targeted therapeutics could have broad clinical applicability for the treatment of tumors.

SUBMITTER: Li X

PROVIDER: S-EPMC9761121 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Tissue factor as a new target for tumor therapy-killing two birds with one stone: a narrative review.

Li Xiaoying X Cao Dan D Zheng Xiufeng X Wang Gang G Liu Ming M

Annals of translational medicine 20221101 22

<h4>Background and objective</h4>Cancer is an important disease and can occur anywhere in the body. It is caused by uncontrolled cell growth that spreads to other body parts. This study extensively investigated the transmembrane receptor tissue factor (TF), which is the key motivator of the clotting cascade and plays an essential role in cancer-associated coagulation. TF is considered to be aberrantly expressed in various tumors and appears to promote tumor angiogenesis and metastasis. Therefore ...[more]

PMID: 36544632

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Dataset Information

Tissue factor as a new target for tumor therapy-killing two birds with one stone: a narrative review.

Background and objective

Methods

Key content and findings

Conclusions

Publications

Tissue factor as a new target for tumor therapy-killing two birds with one stone: a narrative review.

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