Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression.

ABSTRACT: Cancer development is a long-lasting process during which macrophages play a pivotal role. However, how macrophages maintain their cellular identity, persistence, expanding and pro-tumor property during malignant progression remains elusive. Inspired by the recent report of the activation of stem cell-like self-renewal mechanism in mature macrophages, we postulate that intra-tumoral macrophages might be trained to assume stem-like properties and memory-like activity favoring cancer development. Herein we demonstrated that tumor infiltrating macrophages rapidly converted into the CD11b⁺F4/80⁺Ly6C^-Bcl6⁺ phenotype, and adopted stem cell-like properties involving expression of stemness-related genes, long-term persistence and self-renewing. Important

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9771855 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature