A scoping review on early inflammatory bowel disease: definitions, pathogenesis, and impact on clinical outcomes.

ABSTRACT:

Background

Crohn's disease (CD) and ulcerative colitis (UC) arise from a dysregulation of the balance between commensal microbiota and mucosal-associated immune system, in patients with genetic and environmental predisposition. Different pathophysiological mechanisms have been reported to influence disease history, with impact on disease phenotype and risk of complications.

Objectives

This review aims to summarize the definitions of early CD and UC, analyze the underlying immunological mechanisms, and evaluate the impact of recognizing and treating early inflammatory bowel disease (IBD) on patients' prognosis (short- and long-term outcomes).

Design

To address this issue, we have performed a scoping review.

Data sources and methods

Three online databases (MEDLIN

SUBMITTER: Estevinho MM 

PROVIDER: S-EPMC9772959 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature