Discovery of Novel Polycyclic Phloroglucinols via an Improved One-Pot Method.

ABSTRACT: In nature, polycyclic phloroglucinols are a class of compounds with considerable structural diversity and promising biological activities. Herein, we present an improved one-pot method that replaces the solution reaction conditions by mixing the reactants with column chromatography silica gel. Through this convenient, mild, slow, and diversity-oriented strategy, eight structurally unique polycyclic phloroglucinols were discovered, of which compound 1 possesses a rare cage-like skeleton. All compounds determined their structures by X-ray diffraction. Compared with traditional methods, this synthetic strategy produced better diversity and unique structures under milder conditions, suggesting that this method has great potential in lead compound discovery. The optimal reaction conditio

SUBMITTER: Zhu W 

PROVIDER: S-EPMC9774369 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature