Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris.
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SUBMITTER: Pel P
PROVIDER: S-EPMC9774376 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of <i>Lysimachia vulgaris</i>.
Pel Pisey P Kim Young-Mi YM Kim Hyun Ji HJ Nhoek Piseth P An Chae-Yeong CY Son Min-Gyung MG Won Hongic H Lee Seung Eun SE Lee Jeonghoon J Kim Hyun Woo HW Choi Young Hee YH Lee Chang Hoon CH Chin Young-Won YW
ACS omega 20221208 50
A phytochemical investigation of the <i>n</i>-hexane-soluble chemical constituents <i>of</i> <i>Lysimachia vulgaris</i> roots allowed for selection using a proprotein convertase subtilisin-kexin type 9 (PCSK9) mRNA expression monitoring assay in HepG2 cells. This led to the isolation of two previously undescribed isocoumarins of natural origin, 8'Z,11'Z-octadecadienyl-6,8-dihydroxyisocoumarin (<b>1</b>) and 3-pentadecyl-6,8-dihydroxyisocoumarin (<b>2</b>), along with 20 previously reported compo ...[more]
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