Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration.

ABSTRACT: A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC₅₀ values 2-6 fold lower than that of cisplatin, and 30-90 fold lower than that of carboplatin for the tumor cell lines assayed. Comparing the IC₅₀ values between tumor and non-tumor cell lines, the selectivity indexes range from 3.2 to 34, compound 10, [Fe₂(4)₂(CH₃CN)₄](BF₄)₄, showing the highest selectivity. Those compounds carrying substituents on the iminopyridine ring show the same cytotoxicity as those without substituents. However, the electronic effects of the substituents on position 6 may be important for the cytotoxicity of the

SUBMITTER: Castro J 

PROVIDER: S-EPMC9781652 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature