Deciphering the role of RNA structure in translation efficiency.

ABSTRACT:

Background

RNA secondary structure has broad impact on the fate of RNA metabolism. The reduced stability of secondary structures near the translation initiation site/start codon of the coding region promotes the efficiency of translation in both prokaryotic and eukaryotic species. However, the inaccuracy of in silico folding and the focus on the coding region limit our understanding of the global relationship between the whole mRNA structure and translation efficiency. Leveraging high-throughput RNA structure probing data in the transcriptome, we aim to systematically investigate the role of RNA structure in regulating translation efficiency.

Results

Here, we analyze the influences of hundreds of sequence and structural features on translation efficiency in the mouse embryon

SUBMITTER: Lin J 

PROVIDER: S-EPMC9783404 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature