Potential of [¹¹C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model.

ABSTRACT:

Background

Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [¹¹C](R)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model.

Methods

Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [¹¹C](R)-PK11195 and [¹⁸F]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation.

Results

The [¹¹C](R)-PK11195 tumor uptake increased from 3 days to 1 week, and decreased at 2 weeks after cell inoculation, as opposed to the [¹⁸F]FDG uptake, w

SUBMITTER: de Souza AM 

PROVIDER: S-EPMC9786563 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature