Efficacy and Safety of Sugammadex to Shorten Time-to-Extubation Following Cardiac Surgery: A Single-Center Randomized Placebo-Controlled Trial.

ABSTRACT: Residual neuromuscular blockade (NMB) is an important and modifiable factor associated with prolonged mechanical ventilation after cardiac surgery. Studies evaluating the use of sugammadex for residual NMB reversal in the post-cardiac surgery ICU setting are lacking. We conducted a randomized trial to determine the efficacy of sugammadex in reducing time to extubation in patients admitted to the ICU after cardiac surgery.

Design

Single-center, randomized, double-blind, placebo-controlled trial.

Setting

University-based cardiothoracic ICU.

Subjects

Patients (n = 90) undergoing elective aortic valve replacement (AVR) and/or coronary artery bypass grafting (CABG) surgery.

Interventions

Participants were randomized to receive either sugammadex (2 mg/kg) or pl

SUBMITTER: Bardia A 

PROVIDER: S-EPMC9788969 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature