Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy.

ABSTRACT:

Background

DNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns and the direct relationship between cfDNA and apoptosis can potentially be used non-invasively to predict local alterations. In addition, direct detection of altered DNA methylation patterns performs well as a biomarker. In a previous study, we demonstrated marked DNA methylation alterations in brain tissue from patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).

Results

We performed DNA methylation profiling in cfDNA isolated from the serum of MTLE patients and healthy controls using BeadChip arrays followed by systematic bioinfor

SUBMITTER: Martins-Ferreira R 

PROVIDER: S-EPMC9795776 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature