Urolithin B: Two-way attack on IAPP proteotoxicity with implications for diabetes.

ABSTRACT:

Introduction

Diabetes is one of the major metabolic diseases worldwide. Despite being a complex systemic pathology, the aggregation and deposition of Islet Amyloid Polypeptide (IAPP), or amylin, is a recognized histopathological marker of the disease. Although IAPP proteotoxicity represents an important trigger of β-cell dysfunction and ultimately death, its exploitation as a therapeutic tool remains underdeveloped. The bioactivity of (poly)phenols towards inhibition of pathological protein aggregation is well known, however, most of the identified molecules have limited bioavailability.

Methods

Using a strategy combining in silico, cell-free and cell studies, we scrutinized a unique in-house collection of (poly)phenol metabolites predicted to appear in the human circulation

SUBMITTER: Raimundo AF 

PROVIDER: S-EPMC9797523 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature