A robust host-response-based signature distinguishes bacterial and viral infections across diverse global populations.

ABSTRACT: Limited sensitivity and specificity of current diagnostics lead to the erroneous prescription of antibiotics. Host-response-based diagnostics could address these challenges. However, using 4,200 samples across 69 blood transcriptome datasets from 20 countries from patients with bacterial or viral infections representing a broad spectrum of biological, clinical, and technical heterogeneity, we show current host-response-based gene signatures have lower accuracy to distinguish intracellular bacterial infections from viral infections than extracellular bacterial infections. Using these 69 datasets, we identify an 8-gene signature to distinguish intracellular or extracellular bacterial infections from viral infections with an area under the receiver operating characteristic curve (AUROC) > 0.9

SUBMITTER: Rao AM 

PROVIDER: S-EPMC9797950 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature