PET/CT imaging detects intestinal inflammation in a mouse model of doxorubicin-induced mucositis.

ABSTRACT:

Introduction

A severe side effect of cancer chemotherapy is the development of gastrointestinal mucositis, characterised by mucosal inflammation. We investigated if 2-deoxy-2-[¹⁸F] fluoro-D-glucose positron emission tomography combined with computed tomography (2-[¹⁸F]FDG-PET/CT) could visualise gastrointestinal mucositis in mice treated with the chemotherapeutic agent doxorubicin.

Methods

In this study, gastrointestinal inflammation was longitudinally evaluated by 2-[¹⁸F]FDG-PET/CT scans before and 1, 3, 6, and 10 days after treatment with doxorubicin. Doxorubicin-treated mice were compared to saline-treated littermates using the abdominal standard uptake value of 2-[¹⁸F]FDG corrected for body weight (SUV_BW).

Results

SUBMITTER: Dalby S 

PROVIDER: S-EPMC9798215 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature