Protective effect of anakinra on audiovestibular function in a murine model of endolymphatic hydrops.

ABSTRACT:

Introduction

Ménière's disease (MD), a common disease in the inner ear, is characterized by an increase in endolymph in the cochlear duct and vestibular labyrinth. The pathophysiology of the condition appears to be the immune response. Studies have shown that basal levels of the IL-1β increased in some MD patients.

Methods

Here, we used a murine model of endolymphatic hydrops (EH) to study the effect of anakinra on auditory and vestibular function. Mice were intraperitoneal injected with anakinra or saline before LPS by postauricular injection. Weight and disease severity were measured, histologic changes in auditory were assessed, and inflammation state was evaluated.

Results

We found that anakinra therapy reduced LPS-induced EH, alleviated LPS-induced hearing loss a

SUBMITTER: Zhang N 

PROVIDER: S-EPMC9798291 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature