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Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease.

ABSTRACT: COVID-19 is an ongoing worldwide pandemic. Even today, there is a need for the development of effective therapeutic agents. SARS-CoV-2 is known as the causative virus of COVID-19, and its main protease is one of the enzymes essential for its growth and is considered a drug discovery target. In this study, we evaluated the inhibitory activities of a variety of fullerene derivatives, including newly synthesized derivatives, against the main protease of SARS-CoV-2. As a result, the malonic acid-type fullerene derivatives showed the strongest inhibitory activity.

SUBMITTER: Katagishi D

PROVIDER: S-EPMC9798672 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease.

Katagishi Daiki D Yasuda Daisuke D Takahashi Kyoko K Nakamura Shigeo S Mashino Tadahiko T Ohe Tomoyuki T

Bioorganic & medicinal chemistry letters 20221229

COVID-19 is an ongoing worldwide pandemic. Even today, there is a need for the development of effective therapeutic agents. SARS-CoV-2 is known as the causative virus of COVID-19, and its main protease is one of the enzymes essential for its growth and is considered a drug discovery target. In this study, we evaluated the inhibitory activities of a variety of fullerene derivatives, including newly synthesized derivatives, against the main protease of SARS-CoV-2. As a result, the malonic acid-typ ...[more]

PMID: 36587873

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