Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation.

ABSTRACT: Photoswitchable lipids have emerged as attractive tools for the optical control of lipid bioactivity, metabolism, and biophysical properties. Their design is typically based on the incorporation of an azobenzene photoswitch into the hydrophobic lipid tail, which can be switched between its trans- and cis-form using two different wavelengths of light. While glycero- and sphingolipids have been successfully designed to be photoswitchable, isoprenoid lipids have not yet been investigated. Herein, we describe the development of photoswitchable analogs of an isoprenoid lipid and systematically assess their potential for the optical control of various steps in the isoprenylation processing pathway of CaaX proteins in Saccharomyces cerevisiae. One photoswitchable analog of fa

SUBMITTER: Morstein J 

PROVIDER: S-EPMC9799063 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature