Dataset Information

The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work.

ABSTRACT:

Background

Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence is not well defined.

Methods

A literature search was conducted where inclusion required an assessment, by genotype, of postoperative recurrence. The primary endpoint was odds of surgical recurrence.

Results

Twenty-eight studies identified a total of 6715 patients. Thirteen loci were identified as modifying the risk of recurrence. NOD2 was identified as a risk factor for recurrence by multiple works (cumulative odds ratio: 1.64, P = 0.003).

Conclusions

A NOD2 risk allele is associated with recurrence following surgery in Crohn disease. Progress in this area will require standardized reporting in future works.

SUBMITTER: Dang JT

PROVIDER: S-EPMC9802308 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work.

Dang Jerry T JT Dang ThucNhi T TT Wine Eytan E Dicken Bryan B Madsen Karen K Laffin Michael M

Crohn's & colitis 360 20210317 2

<h4>Background</h4>Recurrence following abdominal surgery in Crohn disease is over 50%. The impact of genetics on postoperative recurrence is not well defined.<h4>Methods</h4>A literature search was conducted where inclusion required an assessment, by genotype, of postoperative recurrence. The primary endpoint was odds of surgical recurrence.<h4>Results</h4>Twenty-eight studies identified a total of 6715 patients. Thirteen loci were identified as modifying the risk of recurrence. NOD2 was identi ...[more]

PMID: 36778938

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Dataset Information

The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work.

Background

Methods

Results

Conclusions

Publications

The Genetics of Postoperative Recurrence in Crohn Disease: A Systematic Review, Meta-analysis, and Framework for Future Work.

Similar Datasets

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