Cardiac strain is lower among women with HIV in relation to monocyte activation.

ABSTRACT:

Background

Women with HIV (WWH) face heightened risks of heart failure; however, insights on immune/inflammatory pathways potentially contributing to left ventricular (LV) systolic dysfunction among WWH remain limited.

Setting

Massachusetts General Hospital, Boston, Massachusetts.

Methods

Global longitudinal strain (GLS) is a sensitive measure of LV systolic function, with lower cardiac strain predicting incident heart failure and adverse heart failure outcomes. We analyzed relationships between GLS (cardiovascular magnetic resonance imaging) and monocyte activation (flow cytometry) among 20 WWH and 14 women without HIV.

Results

WWH had lower GLS compared to women without HIV (WWH vs. women without HIV: 19.4±3.0 vs. 23.1±1.9%, P<0.0001). Among the whole group,

SUBMITTER: Toribio M 

PROVIDER: S-EPMC9803182 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature