Prostate cancer cells demonstrate unique metabolism and substrate adaptability acutely after androgen deprivation therapy.

ABSTRACT:

Background

Androgen deprivation therapy (ADT) has been the standard of care for advanced hormone-sensitive prostate cancer (PC), yet tumors invariably develop resistance resulting in castrate-resistant PC. The acute response of cancer cells to ADT includes apoptosis and cell death, but a large fraction remains arrested but viable. In this study, we focused on intensively characterizing the early metabolic changes that result after ADT to define potential metabolic targets for treatment.

Methods

A combination of mass spectrometry, optical metabolic imaging which noninvasively measures drug responses in cells, oxygen consumption rate, and protein expression analysis was used to characterize and block metabolic pathways over several days in multiple PC cell lines with variable

SUBMITTER: Filon MJ 

PROVIDER: S-EPMC9804183 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature