Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.

ABSTRACT:

Objective

The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony. In this study, we aimed to identify and compare features of neural excitability and dynamics across multiple zebrafish seizure and epilepsy models.

Methods

Inspired by video-electroencephalographic recordings in patients, we developed a framework to study spontaneous and photically evoked neural and locomotor activity in zebrafish larvae, by combining high-throughput behavioral tracking and whole-brain in vivo two-photon calcium imaging.

Results

Our setup allowed us to dissect behavioral and physiological features that are divergent or convergent across multiple models. We observed that spontaneous locomotor and neural activity exhibit great

SUBMITTER: Myren-Svelstad S 

PROVIDER: S-EPMC9804334 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature