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Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.

Case presentation

We are presenting a patient with metastatic melanoma who developed severe ICI-induced enterocolitis multirefractory for glucocorticoids, infliximab and vedolizumab, partially responding to faecal microbiota transplantation and final complete response to tofacitinib.

Conclusion

This case supports that tofacitinib may be an(other) effective agent in managing multirefractory ICI-induced diarrhoea caused by colitis and/or enteritis.

SUBMITTER: Holmstroem RB

PROVIDER: S-EPMC9806036 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report.

Holmstroem Rikke Boedker RB Dahl Emilie Kristine EK Helms Morten M Nielsen Henrik Vedel HV Andersen Janne Bayer JB Bjerrum Jacob Tveiten JT Svane Inge Marie IM Ellebaek Eva E Seidelin Jakob Benedict JB

BMJ open gastroenterology 20221201 1

<h4>Background</h4>Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.<h4>Case presentation</h4>We are presenting a patient with metastatic melanoma who developed severe ICI-induced enterocolitis multirefractory for glucocorticoids, infliximab and vedolizumab, partially responding to faecal microbiota transplantat ...[more]

PMID: 36581371

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