Free fatty acids stabilize integrin β₁via S-nitrosylation to promote monocyte-endothelial adhesion.

ABSTRACT: Hyperlipidemia characterized by high blood levels of free fatty acids (FFAs) is important for the progression of inflammatory cardiovascular diseases. Integrin β₁ is a transmembrane receptor that drives various cellular functions, including differentiation, migration, and phagocytosis. However, the underlying mechanisms modifying integrin β₁ protein and activity in mediating monocyte/macrophage adhesion to endothelium remain poorly understood. In this study, we demonstrated that integrin β₁ protein underwent S-nitrosylation in response to nitrosative stress in macrophages. To examine the effect of elevated levels of FFA on the modulation of integrin β₁ expression, we treated the macrophages with a combination of oleic acid and palmitic acid (2:1)

SUBMITTER: Yao Q 

PROVIDER: S-EPMC9808002 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature