Inactivation of SARS-CoV-2 in clinical exhaled breath condensate samples for metabolomic analysis.
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ABSTRACT:
SUBMITTER: Hu S
PROVIDER: S-EPMC9809239 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Inactivation of SARS-CoV-2 in clinical exhaled breath condensate samples for metabolomic analysis.
Hu Shuang S McCartney Mitchell M MM Arredondo Juan J Sankaran-Walters Sumathi S Borras Eva E Harper Richart W RW Schivo Michael M Davis Cristina E CE Kenyon Nicholas J NJ Dandekar Satya S
Journal of breath research 20211220 1
Exhaled breath condensate (EBC) is routinely collected and analyzed in breath research. Because it contains aerosol droplets, EBC samples from SARS-CoV-2 infected individuals harbor the virus and pose the threat of infectious exposure. We report for the first time a safe and consistent method to fully inactivate SARS-CoV-2 in EBC samples and make EBC samples safe for processing and analysis. EBC samples containing infectious SARS-CoV-2 were treated with several concentrations of acetonitrile. Th ...[more]
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