Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse.

ABSTRACT:

Background and hypothesis

Throughout the life stages of women with schizophrenia-spectrum disorders (SSD), lower estrogen levels are associated with more severe disease course. At perimenopause in the mid-forties, estrogen levels decline to remain persistently low after menopause. This period is hypothesized to increase relapse risk and reduce antipsychotic effectiveness in preventing relapse.

Study design

The cohort of persons with schizophrenia/schizoaffective disorder was identified from Finnish nationwide registers (N = 61 889) and stratified by sex and age <45 vs. ≥45 years. Hospitalizations for psychosis were defined per 5-year age group during the follow-up 1996-2017. Risk of psychosis hospitalization (Adjusted Hazard Ratio, aHR) was assessed using within-individual d

SUBMITTER: Sommer IE 

PROVIDER: S-EPMC9810004 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature